81. M. R. S. Nielsen, S. Beyerstedt, H. Zhao, A. E. Kiib, T. B. Poulsen, M. A. Ramos Docampo, “On the synthesis of chiral gold nanorods”, Nanoscale, 2026, DOI: 10.1039/D6NR00823B

First seen on ChemRxiv: doi.org/10.26434/chemrxiv-2025-x82rx

80. B. B. Andersen, S. Kemble, S. Greisen, J. Thyrsted, V. R. Schack, E. Fuchs, A. L. Hansen, T. B. Poulsen, C. K. Holm, D. Olagnier, A. Croft, B. Deleuran, M. A. Nielsen, “4-Octyl itaconate inhibits synovial fibroblast activation by targeting Nrf2 to exert anti-inflammatory effects in rheumatoid arthritis”, EULAR Rheumatol. Open., 2026, 100190, DOI: 10.1016/j.ero.2026.100190

79. T. Bergonci, T. K. Rosenbæk, S. J. Windross, U. B. Keiding, E. Pinilla, K. P. Stuckert, J. Hansen, C. B. Nielsen, J. P. Gomes, L. R. Davies, J. Palmfeldt, V. Loeschcke, C. U. Andersen, U. Simonsen, T. B. Poulsen, M. Johannsen, “Dual pharmacological targeting of coactivator-associated arginine methyltransferase 1 (CARM1) and salt inducible kinase (SIK) drives ketogenesis in both hepatocytes and mice”, Br. J. Pharmacol., 2026, 1–17, DOI: 10.1111/bph.70447

78. K. X. Ali, D. Klenja-Skudrinja, M. Higgins, D. Walker, Y. Sharaf, M. Dankis, A. A. H. Patel, D. Raj, J. J. Dzanan, E. B. Svenningsen, A. Langlands, T. Poulsen, T. Honda, A. T. Dinkova-Kostova, C. Wiel, V. I. Sayin, L. de la Vega, “Development of a high-throughput screening platform for identification of functional BACH1 inhibitors reveals compounds with anti-invasive potential”, Redox Biol., 2026, 94, 104187, DOI: 10.1016/j.redox.2026.104187

77. S. L. B. Møller​, T. B. Poulsen​, “Construction of C(sp3)–C(sp3) attached ring motifs in natural product synthesis”, Nat. Prod. Rep., 2026, DOI: 10.1039/D6NP00024J

76. M. S. Tvilum​, C. B. Nielsen​, I. Steensgaard​, T. B. Poulsen​, M. Johannsen​, T. Tørring, “Hypoxia-induced production of the cyclolipodepsipeptide BE-43547 by Micromonospora sp. RV43”, Microbiology, 2026, 172:001662, DOI: 10.1099/mic.0.001662

75. F. E. H. Kromm*, S. L. B. Møller*, A. S. Jensen, G. J. Wørmer, M. H. Rasmussen, E. B. Svenningsen, T. Tørring, T. B. Poulsen, “Modular Total Synthesis of Lasalocid Acid A through Direct C(sp3)–C(sp3) Attached Ring Construction”, J. Am. Chem. Soc., 2026, 148, 249-257, DOI: 10.1021/jacs.5c11543

*These authors contributed equally

Highlighted in Synfacts: doi.org/10.1055/a-2806-6450

First seen on ChemRxiv: doi.org/10.26434/chemrxiv-2025-4r44q

74. F. Demir, E. Kovalenko, M. Lassé, E. B. Svenningsen, J. M. B. Jensen, A. M. Billing, K. Groeneveld, A. Hutzfeldt, L. Nilges, J. P. L. Guerra, K. J. Pietrzak-Lichwa, Y. Tan, E. Colby, A. G. Hansen, N. Kurmasheva, D. Olagnier, D. Choi, M. M. Richter, S. D. Laufer, F. Braun, S. A. Johnson, M. Krüger, T. B. Huber, E. Hoxha, O. M. Steinmetz, R. Mrowka, S. Melderis, M. A. Saleem, T. B. Poulsen, G. R. Andersen, S. Thiel, A. Troldborg, M. M. Rinschen, “Proteolytic profiling of human plasma reveals an immunoactive complement C3 fragment”, EMBO J., 2025, 44, 7721-7758, DOI: 10.1038/s44318-025-00598-8

73. D. Diprima*, T. T. Paulsen*, A. Pulcinella*, S. Bonciolini, A. L. Gabbey, R. Stuhr, T. B. Poulsen, T. Noël, “Modular Synthesis of Substituted Lactams via a Deoxygenative Photochemical Alkylation–Cyclization Cascade of Secondary Amides in Flow”, JACS Au, 2025, 5, 4584-4592, DOI: 10.1021/jacsau.5c00884

*These authors contributed equally

Highlighted in Synfacts: doi.org/10.1055/a-2783-0105

First seen on ChemRxiv: doi.org/10.26434/chemrxiv-2025-6qf93

72. M. H. Rasmussen, S. L. B. Møller, E. B. Svenningsen, T. Tørring, T. B. Poulsen, “P450 Enzyme LyoI Performs Hydro-2,2′-Bifuran Oxidation in the Polyether Ionophore Lysocellin”, Angew. Chem. Int. Ed., 2025, 64, e202507847, DOI: 10.1002/anie.202507847

First seen on ChemRxiv: doi.org/10.26434/chemrxiv-2025-bdxkm

71. Y. Zhang, G. Renno, G. J. Wørmer, A. M. Tamr, O. Thorn-Seshold, T. B. Poulsen, N. Sakai, S. Matile, “Reversible Conjugate Addition in Thiol-Mediated Uptake”, Helv. Chim. Acta, 2025, 108, e00091, DOI: 10.1002/hlca.202500091

70. M. D. Opfermann, M. B. Søndergård, L. V. Bech, C. B. Nielsen, A. Mahía, C. B. Holt , T. Wang, S. B. Olesen, K. Frisch, J. A. Østergaard, D. Britz, K. L. Nielsen, J. J. Galligan, T. B. Poulsen, J. Hansen, M. Johannsen, “Reactivity-based metabolomics reveal cysteine has glyoxalase 1-like and glyoxalase 2-like activities”, Nat. Chem. Biol., 2025, 21, 1397-1407, DOI: 10.1038/s41589-025-01909-0

69. T. T. Paulsen*, A. E. Kiib*, G. J. Wørmer, S. M. Hacker, T. B. Poulsen, “Total syntheses of cyclohelminthol I–IV reveal a new cysteine-selective covalent reactive group”, Chem. Sci., 2025, 16, 3916-3927, DOI: 10.1039/d4sc08667h

*These authors contributed equally

68. R. N. Ottosen, J. M. Seefeldt, J. Hansen, R. Nielsen, N. Møller, M. Johannsen, T. B. Poulsen, “Preparation and Preclinical Characterization of a Simple Ester for Dual Exogenous Supply of Lactate and Beta-hydroxybutyrate”, J. Agric. Food Chem., 2024, 72, 19883–19890, DOI: 10.1021/acs.jafc.4c04849

67. N. Kurmasheva, A. Said, B. Wong, P. Kinderman, X. Han, A. H. F. Rahimic, A. Kress, M. E. Carter-Timofte, E. Holm, D. van der Horst, C. F. Kollmann, Z. Liu, C. Wang, H.-D. Hoang, E. Kovalenko, M. Chrysopoulou, K. S. Twayana, R. N. Ottosen, E. B. Svenningsen, F. Begnini, A. E. Kiib, F. E. H. Kromm, H. J. Weiss, D. Di Carlo, M. Muscolini, M. Higgins, M. van der Heijden, A. Bardoul, T. Tong, A. Ozsvar, W.-H. Hou, V. R. Schack, C. K. Holm, Y. Zheng, M. Ruzek, J. Kalucka, L. de la Vega, W. A. M. Elgaher, A. R. Korshoej, R. Lin, J. Hiscott, T. B. Poulsen, L. A. O’Neill, D. G. Roy, M. M. Rinschen, N. van Montfoort, J.-S. Diallo, H. F. Farin, T. Alain, D. Olagnier, "Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways", Nat. Commun., 2024, 15, 4096, DOI: 10.1038/s41467-024-48422-x

66. P. Waser, J. Faghtmann, M. Gil-Ordóñez, A. Kristensen, E. B. Svenningsen, T. B. Poulsen, K. A. Jørgensen, “Enantioselective Synthesis of α-Quaternary Isochromanes by Oxidative Aminocatalysis and Gold Catalysis”, Chem. Eur. J., 2024, 30, e202401354, DOI: 10.1002/chem.202401354

65. J. Faghtmann, M. Eugui, J. N. Lamhauge, S. S. P. Andresen, A. R. Østergaard, E. B. Svenningsen, T. B. Poulsen, K. A. Jørgensen, “An Enantioselective Aminocatalytic Cascade Reaction Affording Bioactive Hexahydroazulene Scaffolds”, Chem. Eur. J., 2024, 30, e202401156, DOI: 10.1002/chem.202401156

64. S. L. B. Møller, M. H. Rasmussen, J. Li, E. B. Svenningsen, G. J. Wørmer, T. Tørring, T. B. Poulsen, “The Biological Activities of Polyether Ionophore Antibiotic Routiennocin is Independent of Absolute Stereochemistry”, ChemBioChem, 2024, 25, e202400013, DOI: 10.1002/cbic.202400013

63. M. Busk, P. P. Eggertsen, J. Overgaard, M. R. Horsman, T. Tørring, K. M. Jacobsen, T. B. Poulsen, “In Vitro Characterization of the Bacteria-derived Hypoxia-selective Cytotoxin BE-43547”, Anticancer Res., 2023, 43, 5319-5329, DOI: 10.21873/anticanres.16735

62. F. H. Waqas, M. Shehata, W. A. M. Elgaher, A. Lacour, N. Kurmasheva, F. Begnini, A. E. Kiib, J. Dahlmann, C. Chen, A. Pavlou, T. B. Poulsen, S. Merkert, U. Martin, R. Olmer, D. Olagnier, A. K. H. Hirsch, S. Pleschka, F. Pessler, “NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner”, PLOS Pathog., 2023, 19, e1011506, DOI: 10.1371/journal.ppat.1011506

61. M. Wollesen, K. Mikkelsen, M. S. Tvilum, M. Vestergaard, M. Wang, R. L. Meyer, H. Ingmer, T. B. Poulsen, T. Tørring, “Polyether Ionophore Antibiotics Target Drug-Resistant Clinical Isolates, Persister Cells, and Biofilms”, Microbiol. Spectr., 2023, 11, e00625-23, DOI: 10.1128/spectrum.00625-23

First seen on BioRxiv: doi.org/10.1101/2023.02.13.528344

60. M. Nisavic, G. J. Wørmer, C. S. Nielsen, S. M. Jeppesen, J. Palmfeldt, T. B. Poulsen, “oxSTEF Reagents Are Tunable and Versatile Electrophiles for Selective Disulfide-Rebridging of Native Proteins”, Bioconjugate Chem., 2023, 34, 994-1003, DOI: 10.1021/acs.bioconjchem.3c00005

First seen on ChemRxiv: doi.org/10.26434/chemrxiv-2022-7pkxq

59. A. Mahía, A. E. Kiib, M. Nisavic, E. B. Svenningsen, J. Palmfeldt, T. B. Poulsen, “α-Lactam Electrophiles for Covalent Chemical Biology”, Angew. Chem. Int. Ed., 2023, 62, e202304142, DOI: 10.1002/anie.202304142

First seen on ChemRxiv: doi.org/10.26434/chemrxiv-2022-p4wtd

58. E. B. Svenningsen, R. N. Ottosen, K. H. Jørgensen, M. Nisavic, C. K. Larsen, B. K. Hansen, Y. Wang, K. Lindorff-Larsen, T. Tørring, S. M. Hacker, J. Palmfeldt, T. B. Poulsen, "The Covalent Reactivity of Functionalized 5-Hydroxy-Butyrolactams Is the Basis for Targeting of Fatty Acid Binding Protein 5 (FABP5) by the Neurotrophic Agent MT-21", RSC Chem. Biol., 2022, 3, 1216-1229, DOI: 10.1039/D2CB00161F

57. F. D. Andersen, K. D. Pedersen, D. Wilkens Juhl, T. Mygind, P. Chopin, E. B. Svenningsen, T. B. Poulsen, M. Braad Lund, A. Schramm, C. H. Gotfredsen, T. Tørring, "Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity", J. Nat. Prod., 2022, 85, 1514-1521, DOI: 10.1021/acs.jnatprod.2c00065

56. L. Casares, R. Moreno, K. X. Ali, M. Higgins, S. Dayalan Naidu, G. Neill, L. Cassin, A. E. Kiib, E. B. Svenningsen, A. Minassi, T. Honda, T. B. Poulsen, C. Wiel, V. I. Sayin, A. T. Dinkova-Kostova, D. Olagnier, L. de la Vega, "The Synthetic Triterpenoids CDDO-TFEA and CDDO-Me, but Not CDDO, Promote Nuclear Exclusion of BACH1 Impairing Its Activity", Redox Biol., 2022, 51, 102291, DOI: 10.1016/j.redox.2022.102291

55. G. J. Wørmer, T. B. Poulsen, "The [4.3.0] Piperidine Alkaloids: Architectures, Biology, Biosyntheses and the Complete Details of the Asymmetric Syntheses of Streptazone A and Abikoviromycin", Synlett, 2022, 33, 637-654, DOI: 10.1055/a-1688-0826

54. M. B. Cordon*, K. M. Jacobsen*, C. S. Nielsen, P. Hjerrild, T. B. Poulsen, "Forward Chemical Genetic Screen for Oxygen‐Dependent Cytotoxins Uncovers New Covalent Fragments That Target GPX4", ChemBioChem, 2022, 23, e202100253, DOI: 10.1002/cbic.202100253

*Shared first author

Featured in “Chemical Proteomics and Metabolomics” special edition. Chosen as “Very Important Paper” (VIP).

Featured as front cover

53. H. Liu, R. N. Ottosen, K. M. Jennet, E. B. Svenningsen, T. F. Kristensen, M. Biltoft, M. R. Jakobsen, T. B. Poulsen, "Macrodiolide Diversification Reveals Broad Immunosuppressive Activity That Impairs the CGAS‐STING Pathway", Angew. Chem. Int. Ed., 2021, 60, 18734–18741, DOI: 10.1002/anie.202105793

52. Y. Liu, J. A. Izzo, D. McLeod, S. Ričko, E. B. Svenningsen, T. B. Poulsen, K. A. Jørgensen, "Organocatalytic Asymmetric Multicomponent Cascade Reaction for the Synthesis of Contiguously Substituted Tetrahydronaphthols", J. Am. Chem. Soc., 2021, 143, 8208–8220, DOI: 10.1021/jacs.1c03923

51. L. Dichmann, M. Bregnhøj, H. Liu, M. Westberg, T. B. Poulsen, M. Etzerodt, P. R. Ogilby, "Photophysics of a Protein-Bound Derivative of Malachite Green That Sensitizes the Production of Singlet Oxygen", Photochem. Photobiol. Sci., 2021, 20, 435–449, DOI: 10.1007/s43630-021-00032-y

50. T. B. Poulsen, "Total Synthesis of Natural Products Containing Enamine or Enol Ether Derivatives", Acc. Chem. Res., 2021, 54, 1830–1842, DOI: 10.1021/acs.accounts.0c00851
Contribution to Acc. Chem. Res. special issue on “Total Synthesis of Natural Products”