Gustav's work on the total synthesis of Streptazones and Abikoviromycin is featured on the front cover of Angewandte
49. G. J. Wørmer, N. L. Villadsen, P. Nørby, T. B. Poulsen, "Concise Asymmetric Syntheses of Streptazone A and Abikoviromycin", Angew. Chem. Int. Ed., 2021, 60, 10521–10525, DOI: 10.1002/anie.202101439
Featured as front cover
First seen on ChemRxiv: doi.org/10.26434/chemrxiv.13293356.v1
Our work on expanding the capabilities of the polyether ionophores has been published in Nature Chemistry
48. S. Lin, H. Liu, E. B. Svenningsen, M. Wollesen, K. M. Jacobsen, F. D. Andersen, J. Moyano-Villameriel, C. N. Pedersen, P. Nørby, T. Tørring, T. B. Poulsen, "Expanding the Antibacterial Selectivity of Polyether Ionophore Antibiotics through Diversity-Focused Semisynthesis", Nat. Chem., 2021, 13, 47–55, DOI: 10.1038/s41557-020-00601-1
First seen on ChemRxiv: doi.org/10.26434/chemrxiv.8299715.v1
Read our paper on the discovery of the polyether ionophore X-206 as a potent inhibitor of SARS-CoV-2 infection in vitro
47. E. B. Svenningsen, J. Thyrsted, J. Blay-Cadanet, H. Liu, S. Lin, J. Moyano-Villameriel, D. Olagnier, M. Idorn, S. R. Paludan, C. K. Holm, T. B. Poulsen, "Ionophore Antibiotic X-206 Is a Potent Inhibitor of SARS-CoV-2 Infection in Vitro", Antiviral Res., 2021, 185, 104988, DOI: 10.1016/j.antiviral.2020.104988
First seen on BioRxiv: doi.org/10.1101/2020.06.14.149153
46. D. Olagnier, E. Farahani, J. Thyrsted, J. Blay-Cadanet, A. Herengt, M. Idorn, A. Hait, B. Hernaez, A. Knudsen, M. B. Iversen, M. Schilling, S. E. Jørgensen, M. Thomsen, L. S. Reinert, M. Lappe, H.-D. Hoang, V. H. Gilchrist, A. L. Hansen, R. Ottosen, C. G. Nielsen, C. Møller, D. van der Horst, S. Peri, S. Balachandran, J. Huang, M. Jakobsen, E. B. Svenningsen, T. B. Poulsen, L. Bartsch, A. L. Thielke, Y. Luo, T. Alain, J. Rehwinkel, A. Alcamí, J. Hiscott, T. Mogensen, S. R. Paludan, C. K. Holm, "SARS-CoV2-Mediated Suppression of NRF2-Signaling Reveals Potent Antiviral and Anti-Inflammatory Activity of 4-Octyl-Itaconate and Dimethyl Fumarate", Nat. Commun., 2020, 11, 4938, DOI: 10.1038/s41467-020-18764-3
First seen on BioRxiv: doi.org/10.1101/2020.07.16.206458
Our review on dehydrations is featured on the cover of Natural Product Reports
45. P. Hjerrild, T. Tørring, T. B. Poulsen, "Dehydration Reactions in Polyfunctional Natural Products", Nat. Prod. Rep., 2020, 37, 1043–1064, DOI: 10.1039/D0NP00009D
Featured as front cover
Final publication of our work on the Phenomycin peptide
44. B. K. Hansen, C. K. Larsen, J. T. Nielsen, E. B. Svenningsen, L. B. Van, K. M. Jacobsen, M. Bjerring, R. K. Flygaard, L. B. Jenner, L. N. Nejsum, D. E. Brodersen, F. A. A. Mulder, T. Tørring, T. B. Poulsen "Structure and Function of the Bacterial Protein Toxin Phenomycin", Structure, 2020, 28, 528-539.e9, DOI: 10.1016/j.str.2020.03.003
First seen on BioRxiv: doi.org/10.1101/847772
Collaboratory paper with the Weidner Lab on the analysis of the interaction of Lasalocid acid with membranes
43. T. W. Golbek, L. Schmüser, M. H. Rasmussen, T. B. Poulsen, T. Weidner, "Lasalocid Acid Antibiotic at a Membrane Surface Probed by Sum Frequency Generation Spectroscopy", Langmuir, 2020, 36, 3184–3192, DOI: 10.1021/acs.langmuir.9b03752
42. F. S. Bjørnskov, T. B. Poulsen, "On the Origin of the Blind Chicken Molecule", Nat. Chem., 2020, 12, 2–3, DOI: 10.1038/s41557-019-0390-y
Read our study of a cyclopropene covalently targeting GSTO1 in cells in Angewandte Chemie
41. G. J. Wørmer, B. K. Hansen, J. Palmfeldt, T. B. Poulsen, "A Cyclopropene Electrophile That Targets Glutathione S‐Transferase Omega‐1 in Cells", Angew. Chem. Int. Ed., 2019, 58, 11918–11922, DOI: 10.1002/anie.201907520
Paper describing our work with setting up Cell Painting is just published
40. E. B. Svenningsen, T. B. Poulsen, "Establishing Cell Painting in a Smaller Chemical Biology Lab – A Report from the Frontier", Bioorg. Med. Chem., 2019, 27, 2609–2615, DOI: 10.1016/j.bmc.2019.03.052
Mini review in Angewandte Chemie looking at ionophores
39. H. Liu, S. Lin, K. M. Jacobsen, T. B. Poulsen, "Chemical Syntheses and Chemical Biology of Carboxyl Polyether Ionophores: Recent Highlights", Angew. Chem. Int. Ed., 2019, 58, 13630–13642, DOI: 10.1002/anie.201812982
Paper in Angewandte Chemie describing STEFs: Semi-oxamide vinylogous thioester nucleophilic warheads
38. B. K. Hansen, C. J. Loveridge, S. Thyssen, G. J. Wørmer, A. D. Nielsen, J. Palmfeldt, M. Johannsen, T. B. Poulsen, "STEFs: Activated Vinylogous Protein-Reactive Electrophiles", Angew. Chem. Int. Ed., 2019, 58, 3533–3537, DOI: 10.1002/anie.201814073
37. D. Olagnier, A. M. Brandtoft, C. Gunderstofte, N. L. Villadsen, C. Krapp, A. L. Thielke, A. Laustsen, S. Peri, A. L. Hansen, L. Bonefeld, J. Thyrsted, V. Bruun, M. B. Iversen, L. Lin, V. M. Artegoitia, C. Su, L. Yang, R. Lin, S. Balachandran, Y. Luo, M. Nyegaard, B. Marrero, R. Goldbach-Mansky, M. Motwani, D. G. Ryan, K. A. Fitzgerald, L. A. O’Neill, A. K. Hollensen, C. K. Damgaard, F. v. de Paoli, H. C. Bertram, M. R. Jakobsen, T. B. Poulsen, C. K. Holm, "Nrf2 Negatively Regulates STING Indicating a Link between Antiviral Sensing and Metabolic Reprogramming", Nat. Commun., 2018, 9, 3506, DOI: 10.1038/s41467-018-05861-7
36. N. Hammer, J. D. Erickson, V. H. Lauridsen, J. B. Jakobsen, B. K. Hansen, K. M. Jacobsen, T. B. Poulsen, K. A. Jørgensen, "Catalytic Asymmetric [4+2]‐Cycloadditions Using Tropolones: Developments, Scope, Transformations, and Bioactivity", Angew. Chem. Int. Ed., 2018, 57, 13216–13220, DOI: 10.1002/anie.201808221
New paper in Cell Chemical Biology - Investigating the mode of action of APD-CLD's
35. K. M. Jacobsen, N. L. Villadsen, T. Tørring, C. B. Nielsen, T. Salomón, M. M. Nielsen, M. Tsakos, C. Sibbersen, C. Scavenius, R. Nielsen, E. I. Christensen, P. F. Guerra, P. Bross, J. S. Pedersen, J. J. Enghild, M. Johannsen, J. Frøkiær, J. Overgaard, M. R. Horsman, M. Busk, T. B. Poulsen, "APD-Containing Cyclolipodepsipeptides Target Mitochondrial Function in Hypoxic Cancer Cells", Cell Chem. Biol., 2018, 25, 1337-1349.e12, DOI: 10.1016/j.chembiol.2018.07.010
New paper in Angewandte Chemie - Making heteroatom-functionalized quinones
34. W. Yu, P. Hjerrild, K. M. Jacobsen, H. N. Tobiesen, L. Clemmensen, T. B. Poulsen, "A Catalytic Oxidative Quinone Heterofunctionalization Method - Synthesis of Strongylophorine-26", Angew. Chem. Int. Ed.2018, 57, 9805-9809, DOI: 10.1002/anie.201805580
New paper in JOC - Teasing out the relationsship between the stendomycin and pantomycin natural products
33. N. L. Villadsen, B. K. Hansen, E. B. Svenningsen, K. H. Jørgensen, T. Tørring, T. B. Poulsen, "Stendomycin and Pantomycin are Identical Natural Products – Preparation of a Functionalized Bioactive Analog", J. Org. Chem. 2018, 83, 7303–7308, DOI: 10.1021/acs.joc.8b00553
32. T. Salomón, C. Sibbersen, J. Hansen, D. Britz, M. V. Svart, T. S. Voss, N. Møller, N. Gregersen, K. A. Jørgensen, J. Palmfeldt, T. B. Poulsen, M. Johannsen, ”Ketone Body Acetoacetate Buffers Methylglyoxal via a Non-enzymatic Conversion during Diabetic and Dietary Ketosis”, Cell Chem. Biol. 2017, 24, 935-943, DOI: 10.1016/j.chembiol.2017.07.012
Featured on issue cover
31. E. F. Holmquist, U. B. Keiding, R. Kold-Christensen, T. Salomón, K. A. Jørgensen , P. Kristensen, T. B. Poulsen, M. Johannsen, "ReactELISA: Monitoring a Carbon Nucleophilic Metabolite by ELISA—a Study of Lipid Metabolism" Anal. Chem. 2017, 89, 5066-5071, DOI: 10.1021/acs.analchem.7b00507
30. N. L. Villadsen, K. M. Jacobsen, U. B. Keiding, E. T. Weibel, B. Christiansen, T. Vosegaard, M. Bjerring, F. Jensen, M. Johannsen, T. Tørring, T. B. Poulsen, "Synthesis of ent-BE-43547A1 reveals a potent hypoxia-selective anticancer agent and uncovers the biosynthetic origin of the APD-CLD natural products" Nat. Chem. 2017, 9, 264-272, DOI: 10.1038/nchem.2657
29. H. Feinberg, N. D. S. Rambaruth, S. A. F. Jégouzo, K. M. Jacobsen, R. Djurhuus, T. B. Poulsen, W. I. Weis, M. E. Taylor, K. Drickamer,
"Binding Sites for Acylated Trehalose Analogs of Glycolipid Ligands on an Extended Carbohydrate Recognition Domain of the Macrophage Receptor Mincle" J. Biol. Chem. 2016, 291, 21222-21333, DOI: 10.1074/jbc.M116.749515
28. M. Tsakos, K. M. Jacobsen, W. Yu, N. L. Villadsen, T. B. Poulsen,
"The Rakicidin Family of Anticancer Natural Products – Synthetic Strategies towards a New Class of Hypoxia-Selective Cytotoxins" Synlett. 2016, 27, 1898-1906, DOI: 10.1055/s-0035-1561465
27. W. Yu, P. Hjerrild, J. Overgaard, T. B. Poulsen, "A Concise Route to the Strongylophorines" Angew. Chem. Int. Ed. 2016, 55, 8294-8298, DOI: 10.1002/anie.201602476
Highlighted in Synfacts: doi.org/10.1055/s-0035-1562706
26. M. Tsakos, L. L. Clement, E. S. Schaffert, F. N. Olsen, S. Rupiani, R. Djurhuus, W. Yu, K. M. Jacobsen, N. L. Villadsen, T. B. Poulsen, "Total Synthesis and Biological Evaluation of Rakicidin A and Discovery of a Simplified Bioactive Analogue", Angew. Chem. Int. Ed. 2016, 55, 1030-1035, DOI: 10.1002/anie.201509926
Highlighted in Synfacts: doi.org/10.1055/s-0035-1561118
25. F. N. Olsen, M. Tsakos, T. B. Poulsen, "Npys-Mediated Elimination Reactions of Alcohols and Thiols: A Facile Route to Dehydroalanine and Dehydrobutyrine Building Blocks", Synlett, 2015, 26, 2697-2701, DOI: 10.1055/s-0035-1560537
24. M. Gruca, W. Yu, P. Amoateng, M. A. Nielsen, T.B. Poulsen, H. Balslev, "Ethnomedicinal survey and in vitro anti-plasmodial activity of the palm Borassus aethiopum Mart" J. Ethnopharmacol. 2015, 175, 356-369, DOI: 10.1016/j.jep.2015.09.010
23. L. L. Clement, M. Tsakos, E. S. Schaffert, C. Scavenius, J. J. Enghild, T. B. Poulsen, "The amido-pentadienoate-functionality of the rakicidins is a thiol reactive electrophile – development of a general synthetic strategy" Chem. Commun. 2015, 51, 12427-12430, DOI: 10.1039/C5CC04500B
22. M. Tsakos, E. S. Schaffert, L. L. Clement, N. L. Villadsen, T. B. Poulsen, "Ester Coupling Reactions - An Enduring Challenge in the Chemical Synthesis of Bioactive Natural Products", Nat. Prod. Rep. 2015, 32, 605-632, DOI: 10.1039/C4NP00106K
21. K. M. Jacobsen, U. B. Keiding, L. L. Clement, E. S. Schaffert, N. D. S. Rambaruth, M. Johannsen, K. Drickamer, T. B. Poulsen, "The Natural Product Brartemicin is a High Affinity Ligand for the Carbohydrate-Recognition Domain of the Macrophage Receptor Mincle", Med. Chem. Commun. 2015, 6, 647-652, DOI: 10.1039/C4MD00512K
20. T. B. Poulsen, "A Concise Route to the Macrocyclic Core of the Rakicidins", Chem. Commun. 2011, 47, 12837-12839, DOI: 10.1039/C1CC15829E
![36. N. Hammer, J. D. Erickson, V. H. Lauridsen, J. B. Jakobsen, B. K. Hansen, K. M. Jacobsen, T. B. Poulsen, K. A. Jørgensen, "Catalytic Asymmetric [4+2]‐Cycloadditions Using Tropolones: Developments, Scope, Transformations, and Bioactivity", Angew](https://images.squarespace-cdn.com/content/v1/5b3ddeada2772cc5c397a174/1585396955019-KS28XYJLR41E2L5JM9TW/Angew1.png)
